07/06/2020
The nasal sinus is an incredible immune mediating agent (if we choose to use it).
Breathing through your nose for the majority of times engages a powerful system to prevent infections.
It’s a beautiful balance of cells, mucous and microbes that show how incredible nature can be.
Immune cells in your nose trigger responses and guide the immune system. The problem is that we’ve become disconnected with nasal breathing, and how it is a pillar of our health.
The immunology of the nose is telling us how intricate the nasal sinus is:
In 2008 research demonstrated how viral agents such as rhinovirus (common cold) can infiltrate and kickstart the white blood cell response against it.
We come into contact with pathogens all the time. While such responses are key to maintain health in the face of pathogens, if the nasal immune system is not supported they can also become a source of illness due to resulting inflammation.
This can lead to potentially life-long problems, including tissue swelling, nasal polyp formation, sneezing, stuffy and runny nose, sore throat, cough, headache, chills, fever and difficulty breathing.
The cells of the surface of our nose and sinuses is much more than a protective cover. They are mediators or ‘middlemen’ in disease that result in inflammation too. They signal the immune system and mix information with the nasal microbiome.
Yes, the nose has a microbiome too.
New studies into the microbes that live in the nose also play a mediation role between the infection of agents and communication with the lung microbiome.
When comparing the nasal microbiome in healthy people compared to those with chronic rhinosinusitis they find that healthy people have more DIVERSE nasal microbiomes. They are enriched with streptococcus, haemophilus, and fusobacterium spp. Those with chronic inflammation have less of these bacteria living in the hos.
During the first year of life the nasal microbiome can be measured as determinant of risk of future asthma development and severity of accompanying inflammatory symptoms. The early asymptomatic colonization with Streptococcus in particular being a strong predictor for the future development of asthma. These come from maternal vaginal microbiome and contact with healthy parents.
The nasal microbiome can also influence and modulate infection by other viruses. Studies have compared differences between infants who have had the common cold and those with respiratory syncytial virus.
Today, whilst studies are early, there is developments in the use of probiotics as supportive treatment for those with respiratory issues.
One study showed that Lactobacillus acidophilus 92 in fermented milk significantly improved nasal symptom scores in participants with acute nasal inflmamtion in comparison with the administration of milk without lactic acid bacteria
Other studies show that the effect of Lactobacillus rhamnosus GG and vitamin D supplementation can decrease allergies to grass pollen. They found that there was a decrease in the symptom-medication score in all groups treated.
The tools for immunity are within us if we understand them and use them correctly. Proper dental development is also key to guide a healthy nasal passage.
You can read more on this research via the Johns Hopkins Sinus Center.
Do you suffer with nasal inflammation?