09/27/2026
Sunday Wellness: Peptide Stack
People keep asking what I’m actually using, so here it is.
My approach to aging isn’t about pushing the body harder. It’s about repairing the machinery that makes energy in the first place. That’s the thinking behind the stack I’ve been experimenting with: MOTS-c, SS-31, 5-Amino-1MQ and ipamorelin.
Here’s why each one is in there.
MOTS-c is a peptide your own mitochondria produce. Researchers are looking at how it helps cells switch between burning sugar and burning fat, which is what we mean by metabolic flexibility.
SS-31 (elamipretide) binds to the inner mitochondrial membrane. It’s being studied for helping mitochondria make energy more efficiently, especially under stress.
5-Amino-1MQ blocks an enzyme called NNMT. Less NNMT activity may leave more NAD+ available, and early work suggests effects on fat storage and body composition.
Ipamorelin prompts the pituitary to release growth hormone in a more natural pulse. That can raise IGF-1 and support recovery and lean muscle.
Put together, the idea is simple: better energy production, better metabolic efficiency, better recovery. That’s the environment where training actually pays off and muscle is easier to hold on to as we age. And since chronic metabolic inflammation feeds inflammation everywhere else, including the gums, I care about this as a periodontist too.
Now the part most people skip. This combination has never been tested in controlled human trials. Most of these compounds are still investigational, and none are FDA-approved yet for anti-aging or performance. I’m sharing my reasoning why i take this, not recommending anything. If you’re curious, work with a longevity medicine facility who will run your labs and follow you over time, not someone selling vials online.
🌿 Meraki Integrative Wellness & Longevity | 📍NYC | 📞Telehealth
