06/21/2026
medicine’s favorite mic-drop. But here’s what gets missed: the modern RCT didn’t even exist until 1948 — the first one tested streptomycin for tuberculosis. Everything we understood before that came from a completely different kind of science.
Basic research asks a different question than a trial does. Not “does this work,” but “what is this? What’s normal? What’s healthy?” You have to know what you’re looking at before you can treat it.
A randomized trial is the right tool for “does this treatment work.” But “what is a healthy facial dimension?” isn’t a treatment question — there’s nothing to randomize. That takes a long-term population study measuring real people across age, s*x, and ancestry.
So sometimes “where’s the RCT?” is putting the cart before the horse. A trial tells us if stuff works. A population study tells us what stuff is. Different questions, different tools. 🧠
BasicScience Medicine BeyondTheSmile