16/10/2026
Researchers at Peking University report that periodontitis may push immune cells in the bone marrow into a highly inflammatory state, offering new insight into how gum disease could be linked to conditions such as diabetes.
In the study, published in the International Journal of Oral Science, periodontitis shifted bone marrow neutrophils toward an inflammatory profile. The team traced this to a pathway involving type I interferon signaling and an enzyme called Chac2, which causes glutathione to build up inside these cells and sustains their inflammatory activity.
In diabetic animals with periodontitis, these reprogrammed cells were linked to poorer blood sugar control and impaired pancreatic function. Silencing Chac2 improved both, pointing to the pathway as a potential therapeutic target for periodontitis-associated inflammatory conditions.
This was a mouse study, so further research is needed to confirm whether the same mechanism operates in people.
Source: Niu et al., International Journal of Oral Science, 2026. DOI: 10.1038/s41368-026-00451-6