08/10/2020
🇺🇸 𝗪𝗵𝗲𝗻 𝘁𝗼 𝘀𝗲𝗲 𝗮 𝗱𝗼𝗰𝘁𝗼𝗿 𝗮𝗯𝗼𝘂𝘁 𝗼𝗿𝗮𝗹 𝗹𝗲𝘀𝗶𝗼𝗻𝘀. ℂ𝕙𝕒𝕡𝕥𝕖𝕣 𝟙: Pyogenic granuloma (PG) – also known as lobular capillary hemangioma - is a benign vascular tumour that occurs on the skin and mucous membranes, occasional it can be found subcutaneously or intravascularly. PG can arise spontaneously, in sites of injury, or within capillary malformations. PG has been associated with certain medications such as oral contraceptives, retinoids, gefitinib, cabecitabine, and afatinib. Most tumours occur as solitary lesions, but multiple grouped or disseminated tumours have been described. Multiple disseminated tumours are an adverse cutaneous effect of melanoma treatment with selective BRAF inhibitors like vemurafenib or encorafenib. Multiple periungual PGs occur with targeted oncological therapies using epidermal growth-factor receptor inhibitors or mitogen-activated protein kinase (MEK) inhibitors, and rituximab. PG occurs in all age groups. There is no clear predominance of a gender. PG appear as small or large, smooth or lobulated, reddish exophytic vascular nodules that can grow rapidly. The usual treatment for PG consists of excision, the treatment with the lowest rate of recurrence.
